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Although GLP1RA often cause super-physiological levels of GLP1R activation, this study provides evidence that GLP1R signaling may decrease cancer risk

The follow up duration of the included trials may not be sufficient for the occurrence of carcinogenesis

However, no head-to-head comparisons of GLP-1RAs and other non-insulin glucose-lowering medications exist for patients with NAFLD and type 2 diabetes

Risk of Retained Gastric Contents in Patients Using GLP-1RAs or Tirzepatide Presenting for Endoscopy or General Anesthesia Retrospective studies suggest that individuals on GLP-1-based therapy (exenatide, liraglutide, dulaglutide, semaglutide, or tirzepatide) appear to be at an increased risk of having retained gastric contents [Supplementary Table S3 (21)