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Diabetes Care (2014) 37(10):272330
After 48 weeks, 36%-48% of subjects receiving 8 mg and 12 mg doses achieved 25% weight reduction, with no participants in the placebo group reaching this level
Key Biomarker and Clinical Factors to Assess Before Starting Before considering GLP-1 therapy, several clinical markers and disease characteristics should be evaluated together with your healthcare provider
By contrast, peptides such as PYY and apelin were discontinued primarily due to formulation limitations or tolerability at supraphysiologic dosespharmacologic rather than biological failuresand therefore meet criteria for re-evaluation
