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Fig.2 Pleiotropic effects of GLP1-RA leading to improvement MASLD/MASH [2] GLP-1RA in MASH Treatment: Clinical Progress Several GLP-1RAs and related agents are currently in various phases of clinical development for MASH treatment [4]

Conclusion GI AEs are the most common effects of GLP-1 RAs and dual GIP/GLP-1 RAs, often manifesting during initiation and dose escalation

Clinicians look at your health history to ensure that a low-dose GLP-1 is a safe and effective choice for your body, especially if you have high sensitivity to medications or pre-existing conditions like reflux that might make higher doses difficult to tolerate

This risk is real and is the reason standard clinical practice combines estrogen with progesterone in women who haven't had a hysterectomy