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Collectively, our structures reveal an ago-PAM mechanism for GLP-1R, in which the rearrangement of the conserved polar network is trigged by TM6 movement and stabilized by the ECD-TMD interaction

Each study was systematically reviewed and categorized based on its design, outcomes, and interventions

RosettaDesign was run with chain B (aa 2041) having been set as the designed chain, and chain A set as the target protein

Acute exenatide has been reported to inhibit cocainestimulated locomotor hyperactivity and decrease or abolish cocaineinduced dopamine release in the NAc and lateral septum in mice (Egecioglu, Engel, & Jerlhag, 2013a