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Improving the dysfunctional flora structure is beneficial to the functional recovery after spinal cord injury Short-chain fatty acid regulate the inflammatory process and inhibit the neurotoxicity and secondary injury of microglia Microglia can rapidly transform into activated macrophages and produce toxic molecules that mediate lipid peroxidation, eventually leading to subsequent tissue damage and axonal contraction after SCI (Kigerl et al., 2009)

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