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However, this treatment paradigm demonstrates the acute reduction in apoB48 concentrations in the TRL fraction for 10 h post-injection (37%) compared to placebo controls with a significant decrease in apoB48 production rate, no change in fractional catabolic rate, and no changes in hepatic apoB100 levels were observed (Xiao et al., 2012)
Stocker SL, Morrissey KM, Yee SW et al (2013) The effect of novel promoter variants in MATE1 and MATE2 on the pharmacokinetics and pharmacodynamics of metformin
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