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Obesity rates have almost tripled since 1975, which researchers say is due to a combination of factors, including: Increased access to energy-dense food coupled with reduced physical activity Sleep deprivation Circadian desynchronization Chronic stress A rise in the use of certain medications known to result in weight gain, including some anti-epileptic and psychotropic drugs Other genetic and environmental factors As a result, prescription drug companies have sought their own way to target the treatment of obesity

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Using mice, the researchers investigated two areas in the brain stem, nucleus of the solitary tract (NST) and area postrema (AP), which are linked to feelings of satiety and vomiting responses, respectively

The degree of loose skin depends on age, genetics, how long the excess weight was carried, and how much weight is lost