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Handling Editor : Alejandro Forner Gonzlez Data Availability Statement Data sharing not applicable to this article as no datasets were generated or analysed during the current study

The dual effect on appetite and insulin makes semaglutide a valuable choice for many

-Patients taking Wegovy had an average weight loss of 14.9% after 68 weeks 1 -Patients who took Saxenda had between 5 and 10% weight loss compared with placebo after 56 weeks 2 Medically supervised weight management with GLP-1 prescriptions or refills available online Most GLP-1 side effects are associated with mild abdominal discomfort

-Peptide-oligourea chimeras: stabilization of short -helices by non-peptide helical foldamers