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A total of 13 studies from the past ten years were examined, and while they all showed that losing weight had a good impact on blood pressure, the degree and persistence of this effect differed from study to study

What Does the Evidence Say: A Real-World Comparison Trials comparing Semaglutide vs Tirzepatide One of the most important studies directly compared the two drugs in adults with obesity (but without diabetes)
Expanding the use of GLP-1 receptor agonists across obesity, cardiovascular disease, chronic kidney disease, MASH, and other metabolic disorders requires manufacturers to generate robust long-term clinical evidence for each therapeutic indication

GLP-1 medications may be appropriate if you meet FDA criteria for obesity treatment (BMI 30 or 27 with comorbidities), as weight loss can reduce mechanical stress on lymphatic vessels
