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This was because in contrast to mammals where the islets of Langerhans are embedded in the exocrine pancreas, in fish, the islets reside in a separate organ known as Brockman bodies, thus providing an enriched source of glucagon-producing cells

Gulyaeva NV (2021) Glucocorticoid Regulation of the Glutamatergic Synapse: Mechanisms of Stress_Dependent Neuroplasticity

The pharmaceutical industry also has a role to play

Stomach acid helps eliminate harmful bacteria, so when acid levels drop, more bacteria can survive and upset the balance in your gut
