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These molecules are administered mainly by sub-cutaneous injection, and as such, remain in the peripheral bloodstream for a long period of time (with half-lives of days), but have little access to the intestinal vagal afferents

This distal tubular condition is perceived as a low effective circulating volume stimulus, at the level of juxtaglomerular apparatus, which promotes the inhibition of adenosine production that is associated with a vasodilatory response of the afferent arteriole (33)

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If antiemetics are prescribed, the GI AEs should be monitored and, if they have not reduced once the course of antiemetics is complete, the patient should be switched from the GLP1RA to another glucoselowering therapy