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Some of the adverse effects include: * Vitamin B12 deficiency * Reduced calcium and iron absorption * Osteoporosisrelated fractures * Increased risk of Clostridioides difficile infection * Increase risk of communityacquired pneumonia, particularly in hospitalized or elderly patients * Acute interstitial nephritis * Affect the metabolism of drugs (e.g., clopidogrel, warfarin, diazepam) altering their efficacy

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Patients should factor this full titration curve into their budget planning, not just the starter rate

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