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The cancer question is among the biggest, given the disease's prevalence: Its still the leading cause of death in Canada, and more than four in 10 Canadian men and women will develop some form of it in their lifetime

Both medications work through different mechanisms: metformin improves insulin sensitivity and reduces hepatic glucose production, while semaglutide (a GLP-1 receptor agonist) enhances insulin secretion and slows gastric emptying

However, for inflammatory factors, since there were no changes in gene expression due to the drug treatment, protein levels were not measured

Knudsen and her colleagues also recognized and began studying the powerful weight loss effects of liguratide, and they discovered that it binds to neurons in the arcuate nucleus, a region of the brain involved in regulating food intake and energy expenditure (4)