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Together, these modifications improve bioavailability and decelerate renal clearance [900]

Staying consistent and keeping a positive outlook are very important for long-term success
Because individual responses vary, the clinicians experience and the patients symptom profile guide titration

Shaobo Ding, [email protected] These authors have contributed equally to this work This article was submitted to Experimental Pharmacology and Drug Discovery, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers