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GLP-1RAs (Glucagon-like peptide 1 receptor agonists) benefit not only blood sugar but obese and related metabolic disorders

However, as the effects do not persist over an entire 24 h period, its efficacy at lowering blood glucose levels and reducing body weight is lower than that of GLP-1 receptor agonists with a longer duration of action [3]

Combined with the theory of GIP being an obesogenic hormone (53), these prior findings have highlighted the potential of GIP receptor antagonism, and today the development of GIP receptor antagonists has also emerged as an attractive therapeutic approach for addressing obesity and cardiovascular diseases (54, 55)