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It is engineered to activate three distinct metabolic hormone receptors concurrently: Glucagon-like peptide-1 (GLP-1) receptor Glucose-dependent insulinotropic polypeptide (GIP) receptor Glucagon (GCG) receptor This tri-agonist architecture differentiates GLP-3R from earlier peptide constructs that selectively target only one or two receptor pathways

Eli Lilly and Novo Nordisk are closing in on deals with the Trump administration that would exchange deep discounts on their weight loss drugs for coverage under Medicare, per Endpoints News