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Appetite is reduced in active small bowel CD, and in a subset of patients with IBD, GE is delayed, and prolonged GE is associated with higher disease activity and increased secretion of GLP-1

Larger, more rigorously designed studies are needed before these findings alter clinical practice, she said

A sweeping meta-analysis in The Lancet Diabetes & Endocrinology pooled data from 11 large trials and over 85,000 participants and found that GLP-1 therapies reduced the risk of kidney failure by 16%, slowed significant declines in filtration rate by 22%, and lowered the combined risk of dialysis, severe loss of function, or kidney-related death by 19%

These medications are administered either as subcutaneous injections (weekly or daily, depending on the formulation) or as oral tablets (Rybelsus)