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Semaglutide is a GLP-1 receptor agonist investigated for its effects on glucose homeostasis and appetite regulation

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Patients were stratified according to exposure (n=106,454) or non-exposure (n=317,698) to once-weekly semaglutide, and incidence rates and hazard ratios (HR) of NAION were estimated in a multivariable Cox proportional hazard regression model

This dual synthetic polypeptide, glucose-dependent insulinotropic polypeptide (GIP), and glucagon-like peptide-1 receptor agonist (GLP-1 RA) acts through incretin pathways and stimulates insulin sensitivity while slowing gastric emptying