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Third, efforts were made to minimize potential bias due to heterogenous medication adherence in real-world patients, namely (1) the study cohort was restricted to include only stable users of study drugs to eliminate the potential confounding effect from the short-term use or non-adherence of study drugs and (2) sensitivity analyses were performed based on the AT scenario to estimate treatment effectiveness, with patients who discontinued or switched study drugs censored to corroborate our base-case analysis results based on the ITT scenario

Specialist diabetes services will conduct a thorough assessment, including: Review of your diabetes history and current medications Assessment of cardiovascular risk factors Evaluation of potential contraindications and precautions Discussion of treatment goals, including weight management Education on injection technique (for injectable formulations) Monitoring plan for efficacy and tolerability NICE recommends that GLP-1 therapy should be reviewed at six months