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FDA Drug Safety & Availability (Regulatory Updates / Safety Guidance) Juniper Publishers

However, its effects are of short duration, which may lead to stress reactions and necessitate multiple injections in a short time, making it both time-consuming and costly

When they do occur, the most common side effect is mild nausea and reduced appetiteespecially during the early stages of treatment

It is believed to work through multiple pathways, including: Blocking voltage-gated sodium channels , reducing neuronal excitability Enhancing GABA (gamma-aminobutyric acid) activity , an inhibitory neurotransmitter Antagonising glutamate receptors , further dampening excitatory neurotransmission Inhibiting carbonic anhydrase enzymes , though the clinical significance of this effect is uncertain While topiramate's primary indications are epilepsy and migraine prophylaxis, it has been observed to cause weight loss as a side effect, likely through appetite suppression and altered taste perception
