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Description
Three leptin-deficient adults with a missense mutation of the leptin gene were evaluated during treatment with recombinant methionyl human leptin (r-metHuLeptin), and the therapy was found decrease insulin resistance (Paz-Filho et al., 2008a)

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The excessive caloric intake and micronutrient deficiencies related to obesity after a long-term interdisciplinary therapy
Also the oral absorption of GLP-1 receptor antagonists is extremely low
