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In comparison, although the GLP-1/GIP and GLP-1/GCG dual-agonists also showed a trend toward increased efficacy, their improvement was not as pronounced as that of the tri-agonists
doi: 10.1016/j.obpill.2022.100016 30 JensterleMFerjanSLeaiLSoanAGoriarKZaletelKet al
in the Wang 2023 kidney study it was renoprotective rather than nephrotoxic
Research suggests that the early months after stopping semaglutide may represent a higher-risk period for weight regain, with the trajectory often stabilizing somewhat after this initial phase, though weight typically continues to increase beyond six months
