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Instead of directly stimulating the testes, clomiphene blocks estrogen receptors in the hypothalamus and pituitary
During this time, it was found that 17% of the participants had a history of psychiatric conditions, with insomnia being the most frequently reported issue

20 , 21 This escalation schedule is designed to minimize GI AEs, but if a patient does not tolerate a dose during the escalation period, the subsequent escalation step can be delayed for a further 4 weeks, after which it should be reescalated to 2.4 mg

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