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Apart from inducing cFos activity in the same brain areas [696,726,730], LiCl and central GLP-1R agonism both decrease locomotor activity [668,731], slow GI motility and gastric emptying [573,732], reduce body temperature [732,733], and induce adverse gastrointestinal effects including nausea, emesis, and taste avoidance [696,[724], [725], [726],[734], [735], [736], [737]]

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This is a transitional step ahead of the broader BALANCE model rollout in January 2027, which may expand coverage further