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GLP-1 is an incretin hormone, which means it's released into your gut after you eat

studies have observed that when treatment duration exceeds 20 weeks, and weight loss exceeds 5%, recovery of SHBG and resolution of functional hyperandrogenism are more pronounced and correlate with both baseline HOMA-IR and the magnitude of weight loss (125, 126)

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Niazi and Chatham list several common symptoms that occur when starting GLP-1s or with dose adjustments: Nausea or vomiting Diarrhea or constipation Heartburn or bloating Fatigue Dehydration Muscle loss Some patients may also experience hair thinning with higher doses for prolonged periods, especially when paired with low-calorie intake