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Description
At the time the protocols were finalized, trial results for SURPASS-CVOT were not yet available
(I am a big advocate of spacing out doses for people who have reached their goal weight, OR who are taking GLP-1s primarily for a possible metabolic/anti-inflammatory benefit, and who want to keep their weight neutral.) But maintenance dosing after achieving a clinical response is a completely different concept from starting at a sub-therapeutic dose and hoping it works
However, data is extremely limited
Blood pressure tends to drift upward
