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GIP, or glucose-dependent insulinotropic polypeptide, is another incretin hormone with overlapping but distinct effects on insulin secretion, appetite and metabolism

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Setmelanotide, a selective agonist of the MC4R, is approved by the FDA and EMA for the treatment of obesity and control of hunger in Bardet-Biedl Syndrome or biallelic pro-opiomelanocortin (POMC), proprotein convertase subtilisin/kexin type 1 (PCSK1), or leptin receptor (LEPR) deficiency in affected children above age 2 years-old [103]

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Participants who took zinc had lower fasting glucose levels, improved insulin sensitivity, and reduced HbA1c levels compared to those who did not take zinc

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