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Given the relatively smaller reduction in body weight (9.4%) in the SELECT trial compared to previous RCTs: 14.9% in STEP1 (BMI 37.86.7 kg/m 2 ) [16] and 13.2% STEP6 (BMI 31.9 kg/m 2 ) [49], pleiotropic effects of semaglutide may contribute to the overall CV risk reduction [25,37]

Action Step: Focus on small, consistent additions of high-quality fats to your meals

If sexual health improvements occur, they would likely develop gradually over months as metabolic health improves, not immediately

Practical rule: If a reviewer can understand your weight-loss history in two minutes, your file is much stronger than a folder full of unexplained documents