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Furthermore, we ectopically expressed ER36 in MCF-7 cell line (MCF-7/ER36), which constitutively expresses ER66, or knocked down ER36 with shRNA from MDA-MB 436 cell line (MDA-MB 436/shER36), which lacks endogenous ER66 (Supplementary information, Figures S1A, S3E-S3G)

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Causality between tirzepatide and true gastroparesis has not been established, though rare severe GI motility events have been reported with GLP-1 receptor agonists in postmarketing surveillance

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