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But for those who experience a pronounced "surge and crash" pattern with weekly dosing, where side effects peak in the first 24 to 48 hours and appetite suppression wanes by day five or six, splitting the dose can smooth out the experience considerably

But always keep in mind that, Zepbound being clinically more efficient does not necessarily mean its best for you
For someone with existing hypertension or cardiovascular disease, it could be dangerous

doi: 10.1152/ajpcell.00010.2016