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45 Preclinical studies suggest that GLP-1 RAs may exert anti-inflammatory and cartilage-protective effects within the joint, 46 but further research is needed to determine whether these translate into structural improvements beyond symptomatic relief

Looking forward, the GLP-1 drugs we study (semaglutide, tirzepatide, and emerging oral formulations like orforglipron) are likely only the beginning of a new wave of chronic therapies for conditions like obesity, heart failure, and even kidney disease