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Management for diabetes must therefore be multifaceted, besides simply controlling glucose

The most commonly reported side effects are gastrointestinal in nature and include: Nausea (affecting up to 20-40% of users, particularly during dose escalation) Vomiting and diarrhoea Constipation Abdominal pain and bloating Reduced appetite (which, whilst therapeutically desired, can be excessive in some individuals) Headache and dizziness Injection site reactions (redness, swelling or itching) These effects are typically most pronounced when initiating therapy or increasing doses, which is why gradual titration is recommended

Gastrointestinal Bleed Lower Gastrointestinal Bleeding Lower GI bleeds account for up to one-third of all GI hemorrhages and are frequent causes of admission to the hospital due to their association with increased morbidity and mortality