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95% CI 0.360.49), and TZD (aHR, 0.67

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Although canonically GLP1Rs signal through the stimulatory alpha Gs protein, we find that semaglutide utilizes both Gs- and Gq-signaling pathways in GLP1Rs in the area postrema (AP)the primary site of semaglutide action in the brainto differentially regulate neuronal activation across distinct neuronal clusters

Why This Matters for Clinical & Commercial Strategy: The collaboration signals: Increasing competition in the GLP-1 segment Strategic brand differentiation in high-demand therapies Strong focus on access expansion beyond metro & premium clinics Growing India focus in metabolic & obesity management For professionals in Clinical Research, Market Access, and Business Development, this is a clear indicator of how partnerships are shaping the next phase of diabetes and obesity care in India