is retatrutide a glp 1 drug RETATRUTIDE: Medication for Diabetes and Weight Loss PDB-101: Molecule of the Month:

Different hypotheses are considered, including a compensatory relationship between incretin receptors by which GIPR enhances GLP-1R activity and/or that chronic GIPR agonism produces desensitisation and loss of GIPR activity, thus, mimicking antagonism

Diabetes, obesity and a nationwide drug controversy Ozempic the brand of semaglutide, a GLP-1 receptor agonist, marketed for Type 2 diabetes treatment recently made headlines for a nationwide shortage as its use as a weight loss drug gained popularity

JAMA Surg 158(10):10031011 Miras AD et al (2019) Adjunctive liraglutide treatment in patients with persistent or recurrent type 2 diabetes after metabolic surgery (GRAVITAS): a randomised, double-blind, placebo-controlled trial

Interesting mix of findings