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Targeted digestive support (food tweaks, hydration, fiber, meal timing)

Safety Considerations and Future Outlook As with all pharmacotherapy for obesity and T2D, establishing cardiovascular safety and demonstrating improvements in meaningful clinical outcomes will be essential, particularly as cardiovascular outcome trials have not yet been completed with multi-agonists (although data are expected soon for tirzepatide: SURPASS-CVOT [T2D] in 2025

Participants had a mean baseline HbA1c of 8.28% and a mean baseline weight of 93.7 kg

After reviewing hundreds of cases where people reported Retatrutide failure, I have yet to see one that represented true receptor resistance within the first 12 months