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Key FDA considerations will include the dysesthesia signal (up to 20.9% at the highest dose) and what comorbidity criteria will define the indication
In humans, a clinical study on healthy subjects assessed the effects of GLP-1 infusion on blood pressure and heart rate, and the possible activation of the sympathetic nervous system
Growing evidence suggests that these agents may exert clinically significant effects beyond metabolic pathways as their use continues to expand across diverse patient populations [3]
Despite downward pressure on volumes, overall value impact is more balanced due to a clear shift toward premiumization
