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Avoid refrigerator door storage where temperature fluctuates from opening and closing

PKC activation, particularly the PKC- isoform, enhances ROS production by upregulating NADPH oxidase, a major source of superoxide in the retina

A recent meta-analysis of 11 randomized controlled trials demonstrated a 13-percent relative risk reduction for all-cause death, along with significant risk reductions across multiple outcomes, including 16 percent for renal failure, 13 percent for congestive heart failure hospitalizations, 14 percent for major adverse cardiovascular events, 12 percent for stroke, 13 percent for non-fatal myocardial infarction and 14 percent for cardiovascular death

If you are already taking a medication that topiramate potentially interacts with, ask your healthcare provider for medical advice before making any changes to your drug regimen