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After adjusting for residual confounding, the difference in weight loss between those receiving tirzepatide vs semaglutide was 2.0% (95% CI, 2.1% to 1.8%) at 3 months, 3.2% (95% CI, 3.5% to 3.0%) at 6 months, and 5.1% (95% CI, 5.8% to 4.3%) at 12 months

That is one reason why it is important to look more closely at how semaglutide itself affects the body beyond just weight loss

This third pathway may enhance fat metabolism and energy balance, which is why some people respond differently to retatrutide than to tirzepatide

Can intervals be extended