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Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes

Activation of several receptors may provide non-additive effects, necessitating comprehensive dose-finding studies to reconcile effectiveness with tolerability

While general nausea and vomiting were listed as common side effects, the drug labels did not initially mention the potential for severe, life-altering gastroparesis or other serious complications

FDA approval dates to 1959, making it one of the longest-studied weight-loss agents, though data on long-term safety beyond 12 weeks remains limited