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(2) Mechanistic superiority: Dual inhibition of TBK1 and IKK in eWAT restores AMPK-Thr172 phosphorylation, enhancing mitochondrial biogenesis (via UCP1 upregulation), catecholamine sensitivity (via cAMP upregulation and cAMP-mediated -adrenergic signal transduction) [201, 202]

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Beyond their blood sugar-lowering effects, certain medicationssuch as liraglutide, semaglutide, and tirzepatidehave demonstrated significant effectiveness in promoting weight management, and they have been approved by the Food and Drug Administration (FDA) for long-term obesity treatment