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If side effects are intolerable at a new dose, the standard approach is to drop back to the previous dose for 2 more weeks before attempting the increase again

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The primary outcome was a reduction of at least 17 U/L in ALT, while secondary outcomes included change in BMI z-score, weight and serum markers of metabolic dysfunction-associated comorbidities

[DOI] [PMC free article] [PubMed] [Google Scholar] 11.Contreras C., Gonzalez-Garcia I., Seoane-Collazo P., Martinez-Sanchez N., Linares-Pose L., Rial-Pensado E., Ferno J., Tena-Sempere M., Casals N., Dieguez C., et al