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Bajaj, M.D., from LMC Diabetes and Endocrinology in Brampton, Ontario, Canada, and colleagues examined the efficacy and safety of retatrutide as a monotherapy in a 40-week phase 3 trial involving adults with type 2 diabetes inadequately controlled by diet and exercise alone

over 70% had baseline criteria that met obesity

Log-rank tests compared whether survival curves differed between two cohorts being compared

This inhibition was evidenced by Oil Red O and AdipoRed staining, and by the downregulation of key adipogenic markers, including peroxisome proliferator-activated receptor gamma ( PPAR ), lipoprotein lipase ( LPL ), fatty acid-binding protein 4 ( FABP4 ), and CCAAT/enhancer-binding protein alpha ( C/EBP ) [12, 13, 22, 23]