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Decreased and/or low muscle and bone mass negatively impact health, including physical impairment or disability, falls and fractures, surgical complications, reduced quality of life, and decreased survival

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Intriguingly, the rs1063843 polymorphism that is associated with bipolar disorder and reduced CAMKK2 mRNA expression in the human brain, is also associated with functional impairment of the caudate nucleus [153]

However, only semaglutide, liraglutidethe generic name for Saxenda and Victozaand tirzepatide have been approved by the Food and Drug Administration for weight management