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Insulin, ketone bodies, and mitochondrial energy transduction

MarxNFedericiMSchttKMller-WielandDAjjanRAAntunesMJet al2023 ESC guidelines for the management of cardiovascular disease in patients with diabetes

Orforglipron: The First Approved Oral, Non-Peptide GLP-1R Agonist for Obesity orforglipron oral non-peptide GLP-1R agonist FDA approved for obesity / NDA planned for type 2 diabetes from LLC-PK1 cell HTS + opt N

The results were further supported by confirmatory secondary endpoints showing significant improvements in quality of life (as measured by the Vascular Quality of Life Questionnaire-6 score), including pain-free walking distance and sustained improvement in maximal walking distance at five weeks after stopping therapy