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In the skeletal muscle, leptin stimulates AMPK activity, inactivates the AMP downstream target Acetyl-CoA carboxylase (ACC), and decreases the malonyl CoA levels, hence enhancing the mitochondrial fatty acid oxidation [130, 131]
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10.1161/CIRCRESAHA.116.309726 [DOI] [PubMed] Coskun T, Urva S, Roell WC, Qu H, Loghin C, Moyers JS, OFarrell LS, Briere DA, Sloop KW, Thomas MK, Pirro V, Wainscott DB, Willard FS, Abernathy M, Morford L, Du Y, Benson C, Gimeno RE, Haupt A, Milicevic Z (2022) LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: from discovery to clinical proof of concept
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