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Persistent fatigue beyond 16 weeks, despite adequate nutrition and hydration, points to potential complications like thyroid disease, anemia, or vitamin B12 deficiency

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Other side effects of overly restrictive diets include: Fatigue Lethargy Vitamin and mineral deficiencies Iron, Folate or B12) However, this list is not exhaustive as Dr Tailor explains: 'Restrictive diets can, over a long period of time, reduce fertility, especially for women as their ability to ovulate depends on hormones

Proteomics, transcriptomics and histology Proteomics, bulk RNA sequencing and immunofluorescence was performed as described in Supplementary Information 1