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The reduction in -cell mass in patients with T2DM can be attributed to -cell apoptosis triggered by multiple factors, including islet amyloid deposition, lipotoxicity, glucotoxicity, and inflammation (You et al., 2022)

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A., Tuttle, K
The hallmark of PD is the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc), leading to diminished dopamine levels in the striatum
