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They work through completely different biological pathways

A recent study investigated the effects of GLP-1R agonists in a multi-hit mouse model in which the combination of a high-fat diet and angiotensin II-induced a cardiometabolic HFpEF phenotype that resembles the human HFpEF phenotype to a large extent characterized by obesity, impaired glucose handling, and metabolic dysregulation accompanied by inflammation

Each dose requires 4 to 5 weeks at that level before drug levels stabilize, which is why the standard titration holds each step for 4 weeks

NAFLD can progress from simple steatosis (i.e., nonalcoholic fatty liver [NAFL]) to NASH, cirrhosis, and cancer