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People on the highest dose of retatrutide dropped more than 17% of their body weight, on average, after 24 weeks, and progressed to an average 24% weight loss by the end of 48 weeks, the researchers found
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In one clinical trial, the incidence of hypoglycemia (9.2%) in the group treated with liraglutide (1.2 mg/day) combined with glimepiride was significantly increased compared to the placebo group (2.6%) (15)
Longer fasting may slightly increase GLP-1 after eating
