negatives of retatrutide Diagram showing the mechanism action of Perceived benefits of treatment for
Description
JAMA 2023;330:163140.ArticlePubMedPMC 37
Patients should not discontinue tirzepatide without medical consultation whenever possible, particularly those with diabetes or cardiovascular risk factors
To understand why that happens, we have to look past the weight loss label and into the complex hormonal signaling between the gut and the brain
Another limitation of GLP-1 RAs is that discontinuation commonly leads to substantial body weight regain, and many patients who regain weight subsequently restart GLP-1 RA therapy, resulting in a recurrent cycle of body weight loss and gain [10]
